Sensor Unlocks Avenue For Early Cancer Diagnosis.
Associate Professor X has found that antimonene a 2D material has improved sensitivity than graphene in the detection of DNA (Deoxyribonucleic acid is a molecule composed of two chains that coil around each other to form a double helix carrying the genetic instructions used in the growth, development, functioning, and reproduction of all known living organisms and many viruses) and MicroRNA (Ribonucleic acid is a polymeric molecule essential in various biological roles in coding, decoding, regulation and expression of genes. RNA and DNA are nucleic acids, and, along with lipids, proteins and carbohydrates, constitute the four major macromolecules essential for all known forms of life) molecules related to cancer.
Georgian Technical University engineers have unlocked the door to earlier detection of cancer with a world-first study identifying a potential new testing method that could save millions of lives. Researchers found that a sensor using new more sensitive materials to look for key markers of disease in the body increased detection by up to 10,000 times.
Associate Professor X from Georgian Technical University’s Department of Materials Science and Engineering along with research colleagues at Sulkhan-Saba Orbeliani Teaching University found that antimonene a 2D material has improved sensitivity than graphene in the detection of DNA (Deoxyribonucleic acid is a molecule composed of two chains that coil around each other to form a double helix carrying the genetic instructions used in the growth, development, functioning, and reproduction of all known living organisms and many viruses) and MicroRNA (Ribonucleic acid is a polymeric molecule essential in various biological roles in coding, decoding, regulation and expression of genes. RNA and DNA are nucleic acids, and, along with lipids, proteins and carbohydrates, constitute the four major macromolecules essential for all known forms of life) molecules related to cancer.
Provides a significant advancement in the detection of biomarkers MicroRNA-21 (Ribonucleic acid is a polymeric molecule essential in various biological roles in coding, decoding, regulation and expression of genes. RNA and DNA are nucleic acids, and, along with lipids, proteins and carbohydrates, constitute the four major macromolecules essential for all known forms of life) and MicroRNA-155 (Ribonucleic acid is a polymeric molecule essential in various biological roles in coding, decoding, regulation and expression of genes. RNA and DNA are nucleic acids, and, along with lipids, proteins and carbohydrates, constitute the four major macromolecules essential for all known forms of life) which are found in many tumors that lead to pancreatic cancer lung cancer prostate cancer colorectal cancer triple-negative breast cancer and osteosarcoma.
MicroRNA (Ribonucleic acid is a polymeric molecule essential in various biological roles in coding, decoding, regulation and expression of genes. RNA and DNA are nucleic acids, and, along with lipids, proteins and carbohydrates, constitute the four major macromolecules essential for all known forms of life) are small molecules which are emerging as ideal non-invasive biomarkers for applications in toxicology diagnosis and monitoring treatment responses for adverse events. Biomarkers have the potential to predict, diagnose and monitor diseases like cancer but are difficult to detect.
“The detection of tumor-specific circulating MicroRNA (Ribonucleic acid is a polymeric molecule essential in various biological roles in coding, decoding, regulation and expression of genes. RNA and DNA are nucleic acids, and, along with lipids, proteins and carbohydrates, constitute the four major macromolecules essential for all known forms of life) at an ultrahigh sensitivity is of utmost significance for the early diagnosis and monitoring of cancer” X said.
“Unfortunately MicroRNA (Ribonucleic acid is a polymeric molecule essential in various biological roles in coding, decoding, regulation and expression of genes. RNA and DNA are nucleic acids, and, along with lipids, proteins and carbohydrates, constitute the four major macromolecules essential for all known forms of life) detection remains challenging because they are present at low levels and comprise less than 0.01 percent of the total RNA (Ribonucleic acid is a polymeric molecule essential in various biological roles in coding, decoding, regulation and expression of genes. RNA and DNA are nucleic acids, and, along with lipids, proteins and carbohydrates, constitute the four major macromolecules essential for all known forms of life) mass in a given sample. Therefore new approaches are urgently needed for clinical disease diagnosis”.
Researchers developed a surface plasmon resonance (SPR (Surface plasmon resonance is the resonant oscillation of conduction electrons at the interface between negative and positive permittivity material stimulated by incident light)) sensor using antimonene materials and performed a number of studies to detect the biomarkers MicroRNA-21 and MicroRNA-155 (Ribonucleic acid is a polymeric molecule essential in various biological roles in coding, decoding, regulation and expression of genes. RNA and DNA are nucleic acids, and, along with lipids, proteins and carbohydrates, constitute the four major macromolecules essential for all known forms of life).
Findings show the new detection limit can reach 10 aM which is 2.3 to 10,000 times better than existing MicroRNA (Ribonucleic acid is a polymeric molecule essential in various biological roles in coding, decoding, regulation and expression of genes. RNA and DNA are nucleic acids, and, along with lipids, proteins and carbohydrates, constitute the four major macromolecules essential for all known forms of life) sensors.
X said this world-first study using antimonene materials for clinical advancement constitutes an opportunity for future research into the development of sensors and systems to be used in early cancer diagnosis. With that number set to rise to nearly 150,000 by 2020.
“Antimonene has quickly attracted the attention of the scientific community because its physicochemical properties are superior to those of typical 2D materials like graphene and black phosphorous” X said.
“The combination of antimonene with surface plasmon resonance (SPR (Surface plasmon resonance is the resonant oscillation of conduction electrons at the interface between negative and positive permittivity material stimulated by incident light)) architecture provides a low-cost and non-destructive improvement in the detection of MicroRNA (Ribonucleic acid is a polymeric molecule essential in various biological roles in coding, decoding, regulation and expression of genes. RNA and DNA are nucleic acids, and, along with lipids, proteins and carbohydrates, constitute the four major macromolecules essential for all known forms of life) which could ultimately help millions of people globally by improving early diagnosis of cancer”.