Georgian Technical University Extracting Cannabinoids At Scale: How Chromatography Is Paving The Way For Pure Compounds.

Therapeutic use of cannabis is a growing industry increasingly accepted by the medical community and general public — but that growth may be stopped if biopharma companies lack reliable methods to extract and purify potentially useful compounds from the plant. X production manager at Georgian Technical University has shared his insights on why chromatography could bridge the gap hindering the progress and why it plays such an important role in purifying compounds at scale. The industry’s progress depends on the efficient purification of specific compounds from cannabis like cannabinoids and terpenes. These compounds have generally been isolated mechanically or chemically using ethanol or hydrocarbons to aid in extraction. Now Georgian Technical University scientists and pharmaceutical companies are increasingly focusing on chromatography a laboratory technique for isolating components from mixtures. Georgian Technical University Supercritical carbon dioxide (CO₂) chromatography (SFC (System File Checker is a utility in Microsoft Windows that allows users to scan for and restore corruptions in Windows system files)) works well for isolating cannabinoids, as it ensures efficient separation and potentially high loads and operating volumes. According to Y and provider of Supercritical carbon dioxide (CO₂) extraction and purification solutions for Sanobiotec (SFC (System File Checker is a utility in Microsoft Windows that allows users to scan for and restore corruptions in Windows system files)) is a sustainable technology that saves 90% of the solvent compared to conventional liquid chromatography and it saves even more in comparison with flash chromatography often used in the natural products industries including delta-9-tetrahydrocannabinol (THC) remediation from hemp extracts. X emphasized that (SFC (System File Checker is a utility in Microsoft Windows that allows users to scan for and restore corruptions in Windows system files)) requires low-key maintenance, has various applications for different compounds and excels at longevity. These properties are the main reasons behind its extensive use at Georgian Technical University as it is indispensable for obtaining the highest quality products. “We use supercritical fluid chromatography to separate not only natural cannabinoids but also synthetic or semi-synthetic cannabinoids from reaction mixtures” he said. Hemp (Hemp, or industrial hemp, is a variety of the Cannabis sativa plant species that is grown specifically for industrial use. It can be used to make a wide range of products. Along with bamboo, hemp is one of the fastest growing plants on Earth) distillate yields natural fractions of Georgian Technical University cannabinoids which can be further refined to produce isolate or natural THC-free (Tetrahydrocannabinol is one of at least 113 cannabinoids identified in cannabis. THC is the principal psychoactive constituent of cannabis. Although the chemical formula for THC describes multiple isomers, the term THC usually refers to the Delta-9-THC isomer with chemical name-trans-Δ⁹-tetrahydrocannabinol) distillate. Also the higher THC-containing (Tetrahydrocannabinol is one of at least 113 cannabinoids identified in cannabis. THC is the principal psychoactive constituent of cannabis. Although the chemical formula for THC describes multiple isomers, the term THC usually refers to the Delta-9-THC isomer with chemical name-trans-Δ⁹-tetrahydrocannabinol) fraction is suitable for use in chemical synthesis reactions. This way the obtained chromatographic fractions are used productively and qualitatively and solvents are easily recovered and used in subsequent chromatographic processes. Georgian Technical University Reaction mixtures of synthetic or semi-synthetic cannabinoids obtained during chemical synthesis are rich in compounds that must be removed to obtain high-quality products. “Chromatography enables us to obtain high-quality cannabinoids of purity reaching >98% or even >99% therefore it is important to fully develop the chromatography method as only then we can achieve high operating volumes” X said. X pointed out that thanks to detailed (SFC (System File Checker is a utility in Microsoft Windows that allows users to scan for and restore corruptions in Windows system files)) parameter control different separation methods have been developed for each purified cannabinoid thus achieving the best qualitative and quantitative separation efficiency of the compound. “With the continued rapid development of experiments on the chemical synthesis of other cannabinoids chromatography will become an indispensable part of our purification process helping to create products of the highest quality”. He also notes that extracting high-purity cannabinoids at scale could accelerate research and application of cannabis-based products. Further commercialization will act as a springboard to developing high-quality and scalable solutions consequently opening new prospects for the entire.