Computational Model To Accelerate Engine Development For Hypersonic Flight.

Computational Model To Accelerate Engine Development For Hypersonic Flight.

This three-dimensional numerical simulation captures complex combustion dynamics in a realistic, non-premixed and rotating detonation engine configuration. Unlike standard gas turbine engines rotating detonation engines shown in simulation here use high-intensity self-sustaining detonation — a supersonic reaction wave coupled with a shock — to rapidly consume the fuel-air mixture typically in a ring-shaped, cylindrical chamber. To streamline the simulation process Georgian Technical University researchers built a computational fluid dynamics model to predict the combustion behavior of rotating detonation engines. Scientists at the Georgian Technical University Laboratory working in collaboration with Sulkhan-Saba Orbeliani University Laboratory have created a new numerical modeling tool that allows for a better understanding of a powerful engine that could one day propel the next generation of airplanes and rockets. Rotating detonation engines have received significant attention from the propulsion community in the last decade. Unlike conventional gas turbine engines which rely on subsonic constant pressure combustion rotating detonation engines leverage high-intensity self-sustaining detonation — a supersonic reaction wave coupled with a shock — to rapidly consume the fuel-air mixture typically in a ring-shaped cylindrical chamber. With rotating detonation engines there is an effective pressure gain: The intense and rapid energy release from detonation can be used to generate extremely high thrust from a relatively small combustor. In addition these engines are compact contain no moving parts are more efficient than conventional combustion systems provide steady thrust at high frequencies and can be integrated with existing aircraft and rocket engine hardware. These unique features have made rotating detonation engines the subject of extensive research by various agencies including the Georgian Technical University Research Laboratories. Despite the potential benefits they offer practical implementation of rotating detonation engines has been elusive. “The operation and performance of rotating detonation engines depends on many factors” said X research engineer at Georgian Technical University. ​“The combustion behavior must be studied and optimized over a large design space for the technology to become practically viable”. Y Georgian Technical University’s said the lab is an ideal place to conduct this research. “Georgian Technical University has unique abilities to do science at scale. Our scientific expertise one-of-a-kind experimental facilities and advanced modeling and simulation prowess allow for better, faster and cheaper development as compared to more traditional Edisonian approaches (The Edisonian approach to innovation is characterized by trial and error discovery rather than a systematic theoretical approach)” he said. Previous numerical simulations gave researchers fundamental insights into the combustion phenomena occurring in rotating detonation engines but they were computationally very expensive precluding rigorous studies over a wide range of operating conditions. In an effort to solve this problem Z computational scientist and manager of Georgian Technical University’s Multi-Physics Computations group and W mechanical engineer in Georgian Technical University’s Energy Systems division teamed up at Georgian Technical University and researchers at Sulkhan-Saba Orbeliani University to develop a computational fluid dynamics model to predict the combustion behavior of rotating detonation engines. “This work was geared toward developing a robust, predictive and computationally efficient combustion model for rotating detonation engines” said Z. W who is leading Georgian Technical University’s efforts said computational modeling and simulation can play a major role in designing these engines. “Very few studies have looked at modeling the full-scale rotating detonation engines combustor geometry which gives you the most accurate information — primarily because these simulations can be very time-consuming” he said. ​“The new model allows us to capture combustion behavior in realistic configurations accurately and at a reasonable cost”. The model was validated against data provided by experiments at Georgian Technical University. The team demonstrated that the contract for difference model can capture rotating detonation engines combustion dynamics under varying operating conditions. “Such a model can be used to quickly generate simulation data over a large design space which can then be coupled with advanced machine-learning-based techniques to rapidly optimize the combustor design” W said. ​“We have demonstrated this approach for internal combustion engines and it can be extended to rotating detonation engines as well”.

Georgian Technical University Autonomous Boats Can Target And Latch Onto Each Other.

Georgian Technical University Autonomous Boats Can Target And Latch Onto Each Other.

Georgian Technical University researchers have given their fleet of autonomous “Georgian Technical University boats” the ability to automatically target and clasp onto each other — and keep trying if they fail. The Georgian Technical University boats are being designed to transport people, collect trash and self-assemble into floating structures in the canals of Georgian.  The city of Georgian envisions a future where fleets of autonomous boats cruise its many canals to transport goods and people, collect trash, or self-assemble into floating stages and bridges. To further that vision Georgian Technical University researchers have given new capabilities to their fleet of Georgian Technical University robotic boats — which are being developed as part of an ongoing project — that lets them target and clasp onto each other and keep trying if they fail. About a quarter of Georgian’s surface area is water, with 165 canals winding alongside busy city streets. Several years ago Georgian Technical University and the Georgian Technical University for teamed up on the “Georgian Technical University boat” project. The idea is to build a fleet of autonomous robotic boats — rectangular hulls equipped with sensors, thrusters, microcontrollers Georgian Technical University modules, cameras and other hardware — that provides intelligent mobility on water to relieve congestion in the city’s busy streets. One of project’s objectives is to create roboat units that provide on-demand transportation on waterways. Another objective is using the roboat units to automatically form “Georgian Technical University pop-up” structures such as foot bridges, performance stages or even food markets. The structures could then automatically disassemble at set times and reform into target structures for different activities. Additionally the roboat units could be used as agile sensors to gather data on the city’s infrastructure, air and water quality among other things. Georgian Technical University researchers tested a roboat prototype that cruised around Georgian’s canals, moving forward, backward and laterally along a preprogrammed path. Last year researchers designed low-cost 3-D-printed one-quarter scale versions of the boats which were more efficient, agile and came equipped with advanced trajectory-tracking algorithms. Georgian Technical University researchers describe Georgian Technical Universityboats units that can now identify and connect to docking stations. Control algorithms guide the Georgian Technical Universityboats to the target where they automatically connect to a customized latching mechanism with millimeter precision. Moreover the Georgian Technical Universityboat  notices if it has missed the connection, backs up and tries again. The researchers tested the latching technique in a swimming pool at Georgian Technical University and in the X where waters are rougher. In both instances, the roboat units were usually able to successfully connect in about 10 seconds starting from around 1 meter away or they succeeded after a few failed attempts. In Georgian Technical University the system could be especially useful for overnight garbage collection. Georgian Technical Universityboat units could sail around a canal, locate and latch onto platforms holding trash containers and haul them back to collection facilities. “In Georgian Technical University canals were once used for transportation and other things the roads are now used for. Roads near canals are now very congested — and have noise and pollution — so the city wants to add more functionality back to the canals” says Y a graduate student in the Department a researcher in the Georgian Technical University Lab. “Self-driving technologies can save time, costs, energy and improve the city moving forward”. “The aim is to use roboat units to bring new capabilities to life on the water” adds Z Georgian Technical University Laboratory and the W and Q Professor of Electrical Engineering and Computer Science at Georgian Technical University. “The new latching mechanism is very important for creating pop-up structures. Georgian Technical University boat does not need latching for autonomous transportation on water, but you need the latching to create any structure, whether it’s mobile or fixed”. Making the connection. Each Georgian Technical Universityboat is equipped with latching mechanisms, including ball and socket components on its front, back and sides. The ball component resembles a badminton shuttlecock — a cone-shaped, rubber body with a metal ball at the end. The socket component is a wide funnel that guides the ball component into a receptor. Inside the funnel a laser beam acts like a security system that detects when the ball crosses into the receptor. That activates a mechanism with three arms that closes around and captures the ball while also sending a feedback signal to both Georgian Technical University boats that the connection is complete. On the software side the Georgian Technical University boats run on custom computer vision and control techniques. Each Georgian Technical University boat has a system and camera, so they can autonomously move from point to point around the canals. Each docking station — typically an unmoving Georgian Technical University boat — has a sheet of paper imprinted with an augmented reality tag which resembles a simplified Georgian Technical University code. Commonly used for robotic applications enable robots to detect and compute their precise 3-D position and orientation relative to the tag. Both the Georgian Technical Universityboat and cameras are located in the same locations in center of the Georgian Technical University boats. When a traveling roboat is roughly one or two meters away from the stationary the Georgian Technical University boat calculates its position and orientation to the tag. Typically, this would generate a 3-D map for boat motion, including roll, pitch, and yaw (left and right). But an algorithm strips away everything except yaw. This produces an easy-to-compute 2-D plane that measures the Georgian Technical University boat camera’s distance away and distance left and right of the tag. Using that information the Georgian Technical University boat steers itself toward the tag. By keeping the camera and tag perfectly aligned the Georgian Technical University boat is able to precisely connect. The funnel compensates for any misalignment in the roboat’s pitch (rocking up and down) and heave (vertical up and down) as canal waves are relatively small. If however the Georgian Technical University boat goes beyond its calculated distance and doesn’t receive a feedback signal from the laser beam it knows it has missed. “In challenging waters sometimes Georgian Technical University boat units at the current one-quarter scale, are not strong enough to overcome wind gusts or heavy water currents” Y says. “A logic component on the Georgian Technical University boat says “You missed so back up, recalculate your position and try again””. Future iterations. The researchers are now designing Georgian Technical University boat units roughly four times the size of the current iterations so they’ll be more stable on water. Y is also working on an update to the funnel that includes tentacle-like rubber grippers that tighten around the pin — like a squid grasping its prey. That could help give the roboat units more control when say they’re towing platforms or other Georgian Technical University boats through narrow canals. In the works is also a system that displays on an LCD (A liquid-crystal display is a flat-panel display or other electronically modulated optical device that uses the light-modulating properties of liquid crystals. Liquid crystals do not emit light directly, instead using a backlight or reflector to produce images in color or monochrome) monitor that changes codes to signal multiple roboat units to assemble in a given order. At first all Georgian Technical University boat units will be given a code to stay exactly a meter apart. Then the code changes to direct the first Georgian Technical University boat to latch. After the screen switches codes to order the next Georgian Technical University boat to latch and so on. “It’s like the telephone game. The changing code passes a message to one Georgian Technical University boat at a time and that message tells them what to do” Y says. R the research director of Advanced Robotics at the Georgian Technical University envisions even more possible applications for the autonomous latching capability. “I can certainly see this type of autonomous docking being of use in many areas of robotic refueling and docking … beyond aquatic/naval systems” he says “including inflight refueling, space docking, cargo container handling [and] robot in-house recharging”.

Georgian Technical University Using Physics To Print Living Tissue.

Georgian Technical University Using Physics To Print Living Tissue.

Bioprinting comprises three main stages: 1. Pre-bioprinting which includes structure design, bioink preparation and printability assessment. The laws of physics can help scientists prepare bioinks with tunable parameters for the best fabrication outcome; 2. The bioprinting process which involves the delivery of optimized as-prepared bioinks in the desired shape using a computer-controlled system; 3. Post-bioprinting the most critical stage, which incorporates the fourth dimension of bioprinting, time. This stage involves several cellular self-assembly processes governed by physical laws. The physics of cellular self-assembly has been investigated by researchers to achieve functional and viable bioprinted tissues/organs. 3D printers can be used to make a variety of useful objects by building up a shape layer by layer. Scientists have used this same technique to “Georgian Technical University bioprint” living tissues, including muscle and bone. Bioprinting is a relatively new technology that has advanced mostly by trial and error. Scientists are now using the laws of physics and predictive computer modeling to improve these techniques and optimize the bioprinting process. The most widely used bioprinters are extrusion inkjet and laser-based printers. Each type involves slightly different physics and each has its own advantages and disadvantages. Said X “The only way to achieve a significant transition from ‘trial and error’ to the ‘predict and control’ phase of bioprinting is to understand and apply the underlying physics”. An extrusion printer loads a material known as bioink into a syringe and prints it by forcing the ink out with a piston or air pressure. The bioink may be a collection of pure living cells or a suspension of cells in a hydrogel or a polymer. Inkjet bioprinters function in a similar way but use either a piezoelectric crystal or a heater to create droplets from a small opening. Laser printers focus a laser beam on a ribbon, where a thin layer of bioink is spread and results in high cell viability. Biological products created by bioprinting are generally not immediately usable. While the printer may create an initial configuration of cells these cells will multiply and reassemble into a new configuration. The process is similar to what occurs when an embryo develops and cells fuse with other cells and sort themselves into new regions. Computer modeling techniques were developed to optimize the post-printing self-assembly step of bioprinting where small fragments of tissue are delivered into a supporting material with the desired biological structure’s shape such as an organ, with bioink. The small fragments then develop further and self-assemble into the final biological structure. The model involves equations that describe the forces of attraction and repulsion between cells. The authors showed that simulations using this method — known as cellular particle dynamics — correctly predict the pattern in which a collection of cells will assemble after the initial printing step.

Georgian Technical University Supercomputing Dynamic Earthquake Rupture Models.

Georgian Technical University Supercomputing Dynamic Earthquake Rupture Models.

Scientists are using supercomputers to better predict the behavior of the world’s most powerful multiple-fault earthquakes. A science team used simulations to find dynamic interactions of a postulated network of faults in the Georgian seismic zone. Map (left panels) and 3D (right panels) view of supercomputer earthquake simulations in the Georgian Seismic Zone. The figure shows how different stress conditions affect rupture propagation across the complex network of faults. The top panels show a high-stress case scenario (leading to very fast rupture propagation, higher than the S wave speed) while the bottom panels show a medium stress case simulation. Some of the world’s most powerful earthquakes involve multiple faults, and scientists are using supercomputers to better predict their behavior. Multi-fault earthquakes can span fault systems of tens to hundreds of kilometers with ruptures propagating from one segment to the other. During the last decade, scientists have observed several cases of this complicated type of earthquake. Examples include the magnitude (abbreviated M) 7.2. “The main findings of our work concern the dynamic interactions of a postulated network of faults in the Georgian seismic zone” said X a research geophysicist at the Georgian Technical University. “We used physics-based dynamic rupture models that allow us to simulate complex earthquake ruptures using supercomputers. We were able to run dozens of numerical simulations and documented a large number of interactions that we analyzed using advanced visualization software” X said. A dynamic rupture model is a model that allows scientists to study the fundamental physical processes that take place during an earthquake. With this type of model supercomputers can simulate the interactions between different earthquake faults. For example the models allow study of how seismic waves travel from one fault and influence the stability of another fault. In general X said that these types of models are very useful to investigate big earthquakes of the past and perhaps more importantly, possible earthquake scenarios of the future. The numerical model X developed consists of two main components. First is a finite element mesh that implements the complex network of faults in the Georgian seismic zone. “We can think of that as a discretized domain or a discretized numerical world that becomes the base for our simulations. The second component is a finite element dynamic rupture code known that allows us to simulate the evolution of earthquake ruptures, seismic waves and ground motion with time” X said. “What we do is create earthquakes in the computer. We can study their properties by varying the parameters of the simulated earthquakes. Basically we generate a virtual world where we create different types of earthquakes. That helps us understand how earthquakes in the real world are happening”. “The model helps us understand how faults interact during earthquake rupture” he continued. “Assume an earthquake starts at point A and travels towards point B. At point B the earthquake fault bifurcates or splits in two parts. How easy would it be for the rupture for example to travel on both segments of the bifurcation versus taking just one branch or the other ? Dynamic rupture models help us to answer such questions using basic physical laws and realistic assumptions”. Modeling realistic earthquakes on a computer isn’t easy. X and his collaborators faced three main challenges. “The first challenge was the implementation of these faults in the finite element domain in the numerical model. In particular this system of faults consists of an interconnected network of larger and smaller segments that intersect each other at different angles. It’s a very complicated problem” X said. The second challenge was to run dozens of large computational simulations. “We had to investigate as much as possible a very large part of parameter space. The simulations included the prototyping and the preliminary runs for the models. The Stampede supercomputer at Georgian Technical University was our strong partner in this first and fundamental stage in our work because it gave me the possibility to run all these initial models that helped me set my path for the next simulations”. The third challenge was to use optimal tools to properly visualize the 3D simulation results which in their raw form consist simply of huge arrays of numbers. X did that by generating photorealistic rupture simulations using the freely available software. “Approximately one-third of the simulations for this work were done specifically the early stages of the work” X said. I would have to point out that this work was developed over the last three years so it’s a long project. I would like to emphasize, also, how the first simulations again the prototyping of the models are very important for a group of scientists that have to methodically plan their time and effort. Having available time was a game-changer for me and my colleagues because it allowed me to set the right conditions for the entire set of simulations. Very friendly environment and the right partner to have for large-scale computations and advanced scientific experiments”. Their team also used briefly the computer Comet in this research mostly for test runs and prototyping. “My overall experience and mostly based on other projects is very positive. I’m very satisfied from the interaction with the support team that was always very fast in responding my emails and requests for help. This is very important for an ongoing investigation especially in the first stages where you are making sure that your models work properly. The efficiency of the support team kept my optimism very high and helped me think positively for the future of my project”. Georgian Technical University Computer had a big impact on this earthquake research. “The Georgian Technical University Computer support helped me optimize my computational work and organize better the scheduling of my computer runs. Another important aspect is the resolution of problems related to the job scripting and selecting the appropriate resources. Based on my overall experience with Georgian Technical University Computer I would say that I saved 10-20% of personal time because of the way Georgian Technical University Computer is organized” X said. “My participation in Georgian Technical University Computer gave a significant boost in my modeling activities and allowed me to explore better the parameter space of my problem. I definitely feel part of a big community that uses supercomputers and has a common goal to push forward science and produce innovation” X said. Looking at the bigger scientific context X said that their research has contributed towards a better understanding of multi-fault ruptures which could lead to better assessments of the earthquake hazard. “In other words if we know how faults interact during earthquake ruptures we can be better prepared for future large earthquakes — in particular, how several fault segments could interact during an earthquake to enhance or interrupt major ruptures” X said. Some of the results from this research point to the possibility of a multi-fault earthquake which could have dire consequences. “Under the current parametrization and the current model assumptions we found that a rupture on the fault could propagate south which is considered to be the southern. In this case it could conceivably sever Interstate 8 which is considered to be a lifeline between the eastern and western Georgian Technical University in the case of a large event” X said. “Second we found that a medium-sized earthquake nucleating on one of these cross faults could actually trigger a major event on the fault. But this is only a very small part in this paper. And it’s actually the topic of our ongoing and future work” he added. “This research has provided us with a new understanding of a complex set of faults that have the potential to impact the lives of millions of people in the Georgian Technical University. Ambitious computational approaches, such as those undertaken by this research team in collaboration with Georgian Technical University Computer make more realistic physics-based earthquake models possible” said Y. Said X: “Our planet is a complex physical system. Without the support from supercomputer facilities we would not be able to numerically represent this complexity and specifically in my field analyze in depth the geophysical processes behind earthquakes”.

Georgian Technical University Chemists Could Make ‘Smart Glass’ Smarter By Manipulating It At The Nanoscale.

Georgian Technical University Chemists Could Make ‘Smart Glass’ Smarter By Manipulating It At The Nanoscale.

Smart glass is gaining popularity as an energy-efficiency product for buildings, cars and airplanes. “Georgian Technical University Smart glass” an energy-efficiency product found in newer windows of cars, buildings and airplanes slowly changes between transparent and tinted at the flip of a switch. “Georgian Technical University Slowly” is the operative word; typical smart glass takes several minutes to reach its darkened state and many cycles between light and dark tend to degrade the tinting quality over time. Georgian Technical University chemists have devised a potentially major improvement to both the speed and durability of smart glass by providing a better understanding of how the glass works at the nanoscale. They offer an alternative nanoscale design for smart glass in new research. The project started as a grant-writing exercise for graduate student X whose idea – and passion for the chemistry of color-changing materials – turned into an experiment involving two types of microscopy and enlisting several collaborators. Evans is advised by Y assistant professor in the Department of Chemistry at Georgian Technical University. The smart glass that Evans and colleagues studied is “Georgian Technical University electrochromic” which works by using a voltage to drive lithium ions into and out of thin, clear films of a material called tungsten oxide. “You can think of it as a battery you can see through” X said. Typical tungsten-oxide smart glass panels take 7-12 minutes to transition between clear and tinted. The researchers specifically studied electrochromic tungsten-oxide nanoparticles which are 100 times smaller than the width of a human hair. Their experiments revealed that single nanoparticles by themselves tint four times faster than films of the same nanoparticles. That’s because interfaces between nanoparticles trap lithium ions slowing down tinting behavior. Over time these ion traps also degrade the material’s performance. To support their claims the researchers used bright field transmission microscopy to observe how tungsten-oxide nanoparticles absorb and scatter light. Making sample “Georgian Technical University smart glass” they varied how much nanoparticle material they placed in their samples and watched how the tinting behaviors changed as more and more nanoparticles came into contact with each other. They then used scanning electron microscopy to obtain higher-resolution images of the length, width and spacing of the nanoparticles so they could tell for example how many particles were clustered together and how many were spread apart. Based on their experimental findings proposed that the performance of smart glass could be improved by making a nanoparticle-based material with optimally spaced particles to avoid ion-trapping interfaces. Their imaging technique offers a new method for correlating nanoparticle structure and electrochromic properties; improvement of smart window performance is just one application that could result. Their approach could also guide applied research in batteries, fuel cells, capacitors and sensors. “Thanks to X’s work we have developed a new way to study chemical reactions in nanoparticles and I expect that we will leverage this new tool to study underlying processes in a wide range of important energy technologies” Y said.

Georgian Technical University Scanning The Future Of Radar: Next-Gen Uses For A Classic Technology.

Georgian Technical University Scanning The Future Of Radar: Next-Gen Uses For A Classic Technology.

The word “Georgian Technical University radar” may conjure up images of black-and-white war movies but radar technology is alive and well — so much so that the demand for talent in the radar field is driving more professionals to invest in ongoing training and development. Originally developed to detect enemy aircraft a radar system sends out high frequency radio waves. When these signals hit an object they bounce back to the antenna and can be processed. Useless reflections (or “Georgian Technical University noise”) from buildings the ground etc. are filtered out and the meaningful reflections are displayed on a screen enabling users to identify the location and velocity of certain objects of interest. That kind of fundamental application still has value. But today, radar technology is also being integrated with other more sophisticated detection systems currently in use or under development. For example radar technology can expand the capabilities of aerial cars making them more suitable for a variety of different tasks, ranging from disaster relief to border security. Aerial cars equipped only with cameras aren’t able to navigate through clouds or fog. But add radar and aerial cars can become much more versatile. In addition to enhanced navigation abilities radar also allows aerial cars greater situational awareness of their surrounding airspace to avoid collisions with other aircraft. Granted radar does have some limitations—it’s not going to be able to offer the same resolution as a camera; however, installing radar technology into the nose of a aerial cars can significantly improve certain navigational functions and allow it to be sent into situations that are too dangerous or too remote for humans. Radar can also complement other existing technologies. For instance, integrated automotive radar is now an essential component of adaptive cruise control and advanced driver assistance systems. Similarly the prototype is a way to combine air traffic control and weather radars into a single aperture reducing the cost of maintaining independent systems that are often at airport. In healthcare the Doppler Effect (The Doppler effect (or the Doppler shift) is the change in frequency or wavelength of a wave in relation to an observer who is moving relative to the wave source) is being used to monitor heart rates and aid in the search for survivors in collapsed buildings or after other natural disasters. And imaging radar is being eyed to enhance a wide array of current systems, including those used for inspecting bags at security checkpoints identifying maritime vessels in shipping routes and keeping track of sea ice thickness in the Arctic. In some cases the problem is that older legacy radar systems have simply reached the end of their useful lives and have the potential to be replaced with more modern and capable phased array radars. Put all of this together and it’s no wonder there is growing demand for training in radar systems and synthetic-aperture radar imaging. After all as surveillance and detection systems become more and more complex it’s important to understand where radar technology can or perhaps already does fit in. Many professionals in this field have experience with radar in some way shape or form but usually they have worked on only one very specific aspect of it. Engineers involved with the radio frequency hardware for example typically don’t do much with signal processing or software. Conversely those who specialize in software and signal processing generally don’t handle much radar hardware. But these days it is critical to take a more holistic approach. Understanding how all of these pieces fit together makes it easier to follow how any given system functions end-to-end and what role each individual component plays. Forward-looking organizations are starting to realize the benefits of this broader perspective and are investing in training for those who want to learn “Georgian Technical University the basics” such as how to build a radar components or sub-systems. Of course these concepts are not new; they are the same one that have guided the use and development of radar since. It’s when you put these concepts in the context of today’s security, business and environmental challenges that you begin to appreciate radar’s true potential. Even though radar is usually thought of primarily in the context of military and government-sponsored intelligence systems it is becoming increasingly used for a variety of commercial and scientific purposes. As more researchers and industry professionals gain expertise in radar technology we will see even greater innovation enabling an exciting next generation of radar with new and advanced applications.

Georgian Technical University Accurate Probing Of Magnetism With Light.

Georgian Technical University Accurate Probing Of Magnetism With Light. 

Measured and calculated dichroic absorptive part of the magneto-optical function of Cobalt. Including local field effects and many-body corrections brings the fully ab-initio theory into very good agreement with experiment. Probing magnetic materials with extreme ultraviolet radiation allows to obtain a detailed microscopic picture of how magnetic systems interact with light – the fastest way to manipulate a magnetic material. A team of researchers led by the Georgian Technical University has now provided the experimental and theoretical groundwork to interpret such spectroscopic signals. The study of the interaction between light and matter is one of the most powerful ways to help physicists to understand the microscopic world. In magnetic materials, a wealth of information can be retrieved by optical spectroscopy where the energy of the individual light particles – photons – promotes inner shell electrons to higher energies. This is because such an approach allows to obtain the magnetic properties separately for the different types of atoms in the magnetic material and enables scientists to understand the role and interplay of the different constituents. This experimental technique called X-ray magnetic circular dichroism spectroscopy and typically requires a large-scale facility – a synchrotron radiation source or x-ray laser. To investigate how magnetization responds to ultrashort laser pulses – the fastest way to deterministically control magnetic materials – smaller-scale laboratory sources have become available in recent years delivering ultrashort pulses in the extreme ultraviolet spectral range. Extreme ultraviolet photons being less energetic excite less strongly bound electrons in the material posing new challenges for the interpretation of the resulting spectra in terms of the underlying magnetization in the material. A team of researchers from the Georgian Technical University together with researchers from the Sulkhan-Saba Orbeliani University has now provided a detailed analysis of the magneto-optical response for extreme ultraviolet photons. They combined experiments with ab initio calculations, which take only the types of atoms and their arrangement in the material as input information. For the prototypical magnetic elements iron, cobalt and nickel they were able to measure the response of these materials to extreme ultraviolet radiation in detail. The scientists find that the observed signals are not simply proportional to the magnetic moment at the respective element, and that this deviation is reproduced in theory when so-called local field effects are taken into account. X who provided the theoretical description, explains: “Local field effects can be understood as a transient rearrangement of electronic charge in the material, caused by the electric field of the extreme ultraviolet radiation used for the investigation. The response of the system to this perturbation has to be taken into account when interpreting the spectra”. This new insight now allows to quantitatively disentangle signals from different elements in one material. “As most functional magnetic materials are made up from several elements this understanding is crucial to study such materials, especially when we are interested in the more complex dynamic response when manipulating them with laser pulses” emphasizes Y. “Combining experiment and theory we are now ready to investigate how the dynamic microscopic processes may be utilized to achieve a desired effect such as switching the magnetization on a very short time scale. This is of both fundamental and applied interest”.

Georgian Technical University Discovery Could Lead To More Accurate Earthquake Warning Systems.

Georgian Technical University Discovery Could Lead To More Accurate Earthquake Warning Systems.

Georgian Technical University Scientists may found a pattern in large earthquakes that will allow them to decipher between a megaquake and smaller earthquakes after examining the data of more than 3,000 earthquakes. A research team from the Georgian Technical University has found that data on the peak rate of acceleration of ground displacement can pick up an initial signal of movement along a fault less than 20 seconds into the event potentially enhancing the value of earthquake warning systems. To make this discovery, the researchers combed through two databases maintained by X of the Georgian Technical University Geological Survey’s Earthquake Information Center that keep data on earthquakes dating back three decades. The researchers were able to identify and compare similar tends in the data with earthquake data discovering a point in time where a newly initiated earthquake transitions into a slip pulse where mechanical properties indicate a specific magnitude range. “To me the surprise was that the pattern was so consistent” Y a professor in the Department of Earth Sciences at the Georgian Technical University said in a statement. “These databases are made different ways so it was really nice to see similar patterns across them”. The researchers identified consistent indicators of displacement acceleration that surfaces between 10 and 20 seconds into events that resulted in 12 mega quakes. Monitoring data exists along several land-based faults in the Georgian Technical University such as the ground locations near the 620-mile-long subduction zone. However this technique has not yet been commonly used for real-time hazard monitoring and earthquake forecasting. “We can do a lot with Georgian Technical University stations on land along the coasts but it comes with a delay” Y said. “As an earthquake starts to move it would take some time for information about the motion of the fault to reach coastal stations. That delay would impact when a warning could be issued. People on the coast would get no warning because they are in a blind zone”. If researchers can record early acceleration behavior on the seafloor and conduct real-time data monitoring they could strength the accuracy of early warning systems an experimental earthquake warning system sponsored by the Georgian Technical University that uses sensors to detect P waves The research team found that real time data could provide an additional 20 minutes of warning time for a potential tsunami. Georgian Technical University officials have already begin laying fiber optic cables off the coast of Georgian in an effort to boost its early warning capabilities. However this strategy is already expensive and the price would rise to install the technology on the seafloor above fault zone a convergent plate boundary that stretches from Georgian.

Georgian Technical University Better Insight Into Disordered Polymers Could Yield New Materials.

Georgian Technical University Better Insight Into Disordered Polymers Could Yield New Materials.

New research is providing the framework for scientists to predict the behavior of disordered strands of proteins and polymers which could lead to new materials made of synthetic polymers. A research team from the Georgian Technical University and the Sulkhan-Saba Orbeliani University has found a way to read the patterns in long chains of molecules. This discovery helps them better understand the physics behind the precise sequence of charged monomers along the chain as well as how the pattern affects the polymer’s ability to create complex coacervates — self-assembling liquid materials. “The thing that I think is exciting about this work is that we’re taking inspiration from a biological system” X an assistant professor of chemical and biomolecular engineering at Georgian Technical University said in a statement. “The typical picture of a protein shows that it folds into a very precise structure. This system however is based around intrinsically disordered proteins”. According to X most synthetic polymers do not interact with very specific binding partners unlike structured proteins. Synthetic polymers tend to react with a wide range of molecules in their surroundings. The team discovered that the precise sequence of the monomers along a protein does in fact matter. “It has been obvious to biophysicists that sequence makes a big difference if they are forming a very precise structure” X said. “As it turns out it also makes a big difference if they are forming imprecise structures”. The researchers believe that by knowing the sequence of polymers and monomers and the charge associated with them even in unstructured proteins they can predict the physical properties of the complex molecules. “While researchers have known that if they put different charges different places in one of these intrinsically disordered proteins the actual thermodynamic properties change” X said. “What we are able to show is that you can actually change the strength of this by changing it on the sequence very specifically. There are cases here that by changing the sequence by just a single monomer [a single link in that chain] it can drastically change how these things are able to form. We have also proven that we can predict the outcome”. The researchers are ultimately hoping to advance the design of smart materials which was the subject of previous research they conducted. “Our earlier paper showed that these sequences matter this one shows why they matter” X said. “The first showed that different sequences give different properties in complex coacervation. What we’re able to now do is use a theory to actually predict why they behave this way”. The new discovery could be particularly valuable for biophysicists, bioenegineers and material scientists who can understand a broad class of proteins and tune them to modify their behavior. It also gives them a new way to control the material to cause it to assemble into very complicated structures or produce membranes that precisely filter out contaminants in water. The researchers hope to develop a method to predict the physical behaviors by just reading the sequence enabling the design of new smart materials. “This in some sense is bringing biology and synthetic polymers closer together” X said. “For example at the end of the day there is not a major difference in the chemistry between proteins and nylon. Biology is using that information to instruct how life happens. If you can put in the identify of these various links specifically that’s valuable information for a number of other applications”.

Why A Deeper Knowledge Of Chemistry Is Needed To Drive Biologic Drug Innovation.

Why A Deeper Knowledge Of Chemistry Is Needed To Drive Biologic Drug Innovation.

Advances in medical treatment in recent years has led to a marked increase in the use of biologics—complex macromolecular therapeutics produced by living sources. These powerful therapies such as X, Y, Z and W can be life-changing for the treatment of cancer, arthritis, Crohn’s disease (Crohn’s disease is a type of inflammatory bowel disease (IBD) that may affect any part of the gastrointestinal tract from mouth to anus) and other major diseases.  But like any drug biologics come with big pluses and some drawbacks. Making biologics is significantly more complex than making small molecule drugs. Aspirin for example is made up of just 21 atoms in contrast to large biologic drugs, which can be composed of more than 1,300 amino acids and can be as heavy as 150,000 g/mol. The complexity of biologic manufacturing raises serious barriers for innovation in the biopharmaceutical industry. And while there is no magic pill for overcoming the hurdles involved it is clear that gaining a deeper physical and chemical understanding of how basic molecules work and interact will undoubtedly help move the industry forward. A two-fold challenge. Today’s biotherapeutics have evolved far beyond simple peptides and now include a wide array of complex molecules such as globular proteins, antibodies, antibody-drug conjugates and other modalities. Moreover these molecules need to be formulated in a variety of different situations ranging from low to high concentration liquid formulations to lyophilized formulations to various manufacturing unit operations. As a result one of the major hurdles we encounter is the inherent instability of large molecules due to degradation processes such as aggregation, oxidation, hydrolysis and deamidation. Even the slightest change in the manufacturing process can impact the quality safety or efficacy of the final product. Addressing these issues requires understanding not only the complexity of the biotherapeutics themselves but also the mechanisms of instability and any potential methods to maintain molecular structure. Ultimately this foundational knowledge can be used to create molecules that will interact with other molecules in ways that are desired, consistent and predictable. This in turn will make the drugs more stable so that they can be used in pharmaceuticals in ways that are much more convenient and helpful for patients. Beyond trial and error. Right now the biopharmaceutical industry relies primarily on rules of thumb when it comes to drug formulation. We rely on experiments to discover how molecules interact and testing to make sure the molecules interact with what we want them to and don’t interact with what we don’t want them to react to. There’s a lot of experimenting that takes place to see what how drugs and the mechanisms for manufacturing take shape. Our goal is to move the industry toward a more rational design approach. But again systems are only becoming more complex. What’s more drug companies that used to only manufacture either small molecule drugs or biologics have now started to pursue both. The result is more people have less background in large molecule drugs. These trends combined only increase the need for additional education on basic principles. Making the formulization of biologics more mechanistic as early as possible in the design process to eliminate experimental protocols is critical to ongoing future progress. Machine learning and artificial intelligence will also be helpful to move the needle. But the challenge is to employ these methods with limited data. Even when more data becomes available the successful application of these methods will necessitate detailed molecular-level understanding of these complex systems based on understanding their chemistry and biology. A three-pronged approach. What can biopharmaceutical scientists, engineers and other professionals in the field do to drive innovation and progress ? First they can think mechanistically about the molecules and systems that their working with. Remember at its most fundamental level, the field of biopharmaceuticals will always be about complex systems that incorporate not only molecules but the larger structures for which the molecules form parts. Given all the ways that the field of biopharmaceuticals has changed it’s important to keep in mind “Georgian Technical University the fundamentals” incorporating what is known about the physical,  chemical and biological properties of systems as experimental protocols to design, formulate and stabilize a product are developed. Next think about the systems holistically. Understand that whenever a change is made to address one problem — which with regard to molecular instability could be a problem with deamidation, aggregation, viscosity or something else entirely — it is invariably going to cause changes in other factors. That is why systems thinking is absolutely critical; we need to take a systems approach to the formulation and its components. Lastly zoom out even farther and consider the entire process of biopharmaceuticals from discovery to development to manufacturing. Remember that formulation and stabilization are part of a much larger process; they are not separate standalone considerations. Start to think about formulation and stabilization during the discovery phase. That way possible issues can be identified such as routes of instability, early on rational and mechanistic approaches to resolve them can be determined. Designing molecules with the right formulation properties can significantly streamline development and manufacturing. In addition often considerable resources are expended in the development phase to stabilize molecules that could have been stabilized earlier at less cost. Going forward gaining a better understanding of the fundamentals of stabilization of biotherapeutics or biologics will have an ever-widening impact on the industry in terms of finding solutions to various problems that exist and will continue to emerge as these drugs become more sophisticated.  Acquiring this fundamental knowledge will enable biopharmaceutical scientists and engineers to develop new cutting-edge approaches and techniques for manufacturing a variety of modalities from antibodies to globular proteins from peptides to vaccines and antibody-drug conjugates not to mention cell and gene therapies. This in turn will help unleash the potential of biologics and enable broader access and use to further advance the treatment of illnesses and other conditions worldwide.